tag:blogger.com,1999:blog-4915638391882791210.post1446015220870267177..comments2024-03-28T15:39:34.208+01:00Comments on Salud, dinero y atenciĆ³n primaria: Sacubitril/valsartan in heart failure: a critical review of the PARADIGM-HF trialUnknownnoreply@blogger.comBlogger1125tag:blogger.com,1999:blog-4915638391882791210.post-77965349994927258692018-11-15T17:56:32.770+01:002018-11-15T17:56:32.770+01:00Sacubitril, also known as AHU377 or LCZ696, is ang... Sacubitril, also known as AHU377 or LCZ696, is angiotensin receptor neprilysin inhibitor being studied for use in combination with valsartan for heart failure. Sacubitril is a prodrug that is activated to LBQ657 by de-ethylation via esterases. LBQ657 inhibits the enzyme neprilysin, which is responsible for the degradation of atrial and brain natriuretic peptide, two blood pressure lowering peptides that work mainly by reducing blood volume. <a href="https://www.bocsci.com/ahu-377-cas-149709-62-6-item-84-458470.html" rel="nofollow">AHU-377</a><br />Anonymoushttps://www.blogger.com/profile/12128271861530734257noreply@blogger.com